AstraZeneca favors, organ chip technology is expected to accelerate the discovery of new drugs
AstraZeneca favors, organ chip technology is expected to accelerate the discovery of new drugs
May 21, 2018 Source: WuXi PharmaTech
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, Emulate, based in Boston, USA, reached an agreement with AstraZeneca's Innovative Medicines and Early Development (IMED) Biotechnology Division to integrate its organ-based (Organs-on-Chips) technology into AstraZeneca's IMED. In the drug safety laboratory.
AstraZeneca is the first pharmaceutical company to work with Emulate to integrate organ chip technology into its in-house laboratory. Since 2013, AstraZeneca has been working with Emulate on organ chip technology. The two companies announced some recent work at the Society of Toxicology annual meeting in March 2018. Emulate said the agreement with AstraZeneca will accelerate the testing and development of organ chip technology in the pharmaceutical company environment. Dr. Mene Pangalos, executive vice president and head of IMED Biotechnology at AstraZeneca, said that organ chip technology "has the potential to enhance and accelerate our ability to turn science into innovative drugs for patients."
Emulate's organ chips are similar in size to USB disks, and they have hollow channels with linings of tens of thousands of living human cells and tissues. These organ chips are a living microenvironment that can be viewed as a scaled-down liver, lung, and intestine that mimics complex and specialized human organ characteristics and is therefore suitable for testing the metabolism and functioning of drugs in the human body. Promote the development of new therapies. Emulate's technology reproduces the dynamics of normal functioning in human organs, overcoming the limitations that may exist in current preclinical trials. It is worth mentioning that immune cells can also be introduced into the system, allowing researchers to better study antibody and drug combinations. In addition, researchers can use organ chips to better understand disease mechanisms, detect biomarkers earlier, improve the predictability of biomarkers, and reduce the use of laboratory animals. In the future, it is even possible to isolate cells from patients, build organ chips, test the safety of drugs in an individualized way, and understand the effects of diseases or therapies on different individuals.
The initial focus of Emulate's collaboration with AstraZeneca will be to use Emulate's liver chip for safety testing in drug candidates for the AstraZeneca R&D pipeline, with the goal of submitting organ chip data within the framework of new drug regulation. Last year, Emulate and the US FDA signed a collaborative research and development agreement to evaluate Emulate's organ chip technology. They will determine if the technology has sufficient toxicology testing capabilities to meet the regulatory evaluation criteria for new products. Emulate said that the terms of the agreement with AstraZeneca will allow AstraZeneca to adopt liver chip technology in the medical field and enable the two companies to develop three other types of simulated organ chips, including lung tumor chips, lung chips and glomeruli. Kidney chip.
â–² Only the size of the USB disk organ is expected to accelerate the development of new drugs (Source: Emulate official website)
"The collaborative research with AstraZeneca will enable us to further develop the organ chip platform and add more functionality to it," said Dr. Geraldine Hamilton, President and Chief Scientific Officer of Emulate.
“Working side by side with Emulate scientists will enable us to better develop the platform and help us better predict the side effects of drugs in the human body. This partnership reflects our commitment to creating a permeable research environment. Scientists from all walks of life work together to promote scientific progress," Dr. Mene Pangalos of AstraZeneca said in a statement.
Reference materials:
[1] Emulate, Inc. and AstraZeneca Collaborate on Organs-on-Chips Technology
[2] WuXi PharmaTech - Roche Takeda are optimistic, organ chips are expected to accelerate the discovery of new drugs
We are manufacturer of First Aid Bag And Box in China, if you want to buy Trauma First Aid Bag,Medical Emergency Plastic Box,Tactical Medical First Aid Kit Case please contact us.
First Aid Bag And Box,Trauma First Aid Bag,Medical Emergency Plastic Box,Tactical Medical First Aid Kit Case
Medton Medical , https://www.medtonmedical.com