CAS 27262-48-2 Anesthetic Levobupivacaine Hydrochloride / Levobupivacaine HCl

CAS 27262-48-2 Anesthetic Levobupivacaine Hydrochloride / Levobupivacaine HCl


Basic Info

Product Name:Levobupivacaine hydrochloride
CAS NO.:27262-48-2
Molecular Formula:C18H28N2O.HCl
Molecular Weight:324.89
Appearance:white powder
Purity:99%
Grade:Pharmaceutical Grade


 
 

Description:

Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine,it is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine.

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

Levobupivacaine is an amide-type local anaesthetic. Levobupivacaine acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Localised and reversible anaesthesia is produced by interference with the opening of the sodium channel, which inhibits conduction of the action potential in nerves involved in sensory and motor activity and sympathetic activity. Levobupivacaine displaces 3H-BTX from sodium channels of rat brain synaptosomes with IC50 of 2.9 μM and Hill coefficients of 1.2. When cell membrane is held at -80 mV, -70 mV, -60 mV or -100 mV, Levobupivacaine shows tonic inhibition of sodium channel in GH3 cells with IC50s of 132.1, 37.6, 21.6 and 264 μM, respectively. Levobupivacaine depresses action potential of isolated axon in vitro. Levobupivacaine (1mM) depresses action potential amplitude and maximal rate of rise of action potential (dV/dtmax) in the crayfish giant axons with value of 88 and 81 respectively, after perfusion for 15 min. [3] Levobupivacaine also displays activity on cardiac ion channels. In isolated ventricular myocytes, the apparent affinity for inactivated state of the sodium channel is 4.8 μM for Levobupivacaine, with a calculated KD of 39μM. On inhibition of cardiac delayed rectifier potassium channels (hKv1.5), the steady-state block for Levobupivacaine (20 μM) is 31%, with a calculated KD of 27.3 μM. Levobupivacaine may also inhibit cardiac calcium channels. 10 μM Levobupivacaine produces a 50% decrease in contractile force of guinea-pig papillary muscles. 

Levobupivacaine has similar nerve blocking potency with bupivacaine. Levobupivacaine at a dose of 0.125%, inhibits motor and nocifensive pinch responses with maximum %MPE of 99 and 68 respectively, and inhibits the duration of deficits of motor and nocifensive pinch responses (60 and 30 , respectively) after sciatic nerve block.

Application:

Local infiltration anesthesia, local wound analgesia, epidural analgesia or postoperative analgesia; nerve block and epidural anesthesia and local anesthesia.

Usage and dosage:

1. Commonly used 0.75% bupivacaine and 2% lidocaine mixture (1:1) for orbicularis oculi muscle anesthesia and ball anesthesia, the total amount of 7 ~ 9ml (not more than) 12ml get good results.

2.0.25% ~ 0.75% of the eye, 5 ~ 11min and produce surface local anesthetic effect, sustained 4 ~ 7.5h.

3.0.125%-0.25% for local infiltration anesthesia, local wound analgesia, postoperative analgesia.

4.0.25% ~ 0.5% for nerve block anesthesia, the maximum dose of 200mg.

5.5% for epidural anesthesia: adult safe dose 150mg, maximum 200mg each, daily 400mg.

6. The concentration of each concentration of light, medium and heavy gravity concentration, can be used for spinal anesthesia, the amount does not exceed 15mg.
 

.

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.
 

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 




Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.

Please feel free to contact me if you need any further information~






  CAS 27262-48-2 Anesthetic Levobupivacaine Hydrochloride / Levobupivacaine HCl


Basic Info

Product Name:Levobupivacaine hydrochloride
CAS NO.:27262-48-2
Molecular Formula:C18H28N2O.HCl
Molecular Weight:324.89
Appearance:white powder
Purity:99%
Grade:Pharmaceutical Grade


 
 

Description:

Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine,it is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine.

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

Levobupivacaine is an amide-type local anaesthetic. Levobupivacaine acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Localised and reversible anaesthesia is produced by interference with the opening of the sodium channel, which inhibits conduction of the action potential in nerves involved in sensory and motor activity and sympathetic activity. Levobupivacaine displaces 3H-BTX from sodium channels of rat brain synaptosomes with IC50 of 2.9 μM and Hill coefficients of 1.2. When cell membrane is held at -80 mV, -70 mV, -60 mV or -100 mV, Levobupivacaine shows tonic inhibition of sodium channel in GH3 cells with IC50s of 132.1, 37.6, 21.6 and 264 μM, respectively. Levobupivacaine depresses action potential of isolated axon in vitro. Levobupivacaine (1mM) depresses action potential amplitude and maximal rate of rise of action potential (dV/dtmax) in the crayfish giant axons with value of 88 and 81 respectively, after perfusion for 15 min. [3] Levobupivacaine also displays activity on cardiac ion channels. In isolated ventricular myocytes, the apparent affinity for inactivated state of the sodium channel is 4.8 μM for Levobupivacaine, with a calculated KD of 39μM. On inhibition of cardiac delayed rectifier potassium channels (hKv1.5), the steady-state block for Levobupivacaine (20 μM) is 31%, with a calculated KD of 27.3 μM. Levobupivacaine may also inhibit cardiac calcium channels. 10 μM Levobupivacaine produces a 50% decrease in contractile force of guinea-pig papillary muscles. 

Levobupivacaine has similar nerve blocking potency with bupivacaine. Levobupivacaine at a dose of 0.125%, inhibits motor and nocifensive pinch responses with maximum %MPE of 99 and 68 respectively, and inhibits the duration of deficits of motor and nocifensive pinch responses (60 and 30 , respectively) after sciatic nerve block.

Application:

Local infiltration anesthesia, local wound analgesia, epidural analgesia or postoperative analgesia; nerve block and epidural anesthesia and local anesthesia.

Usage and dosage:

1. Commonly used 0.75% bupivacaine and 2% lidocaine mixture (1:1) for orbicularis oculi muscle anesthesia and ball anesthesia, the total amount of 7 ~ 9ml (not more than) 12ml get good results.

2.0.25% ~ 0.75% of the eye, 5 ~ 11min and produce surface local anesthetic effect, sustained 4 ~ 7.5h.

3.0.125%-0.25% for local infiltration anesthesia, local wound analgesia, postoperative analgesia.

4.0.25% ~ 0.5% for nerve block anesthesia, the maximum dose of 200mg.

5.5% for epidural anesthesia: adult safe dose 150mg, maximum 200mg each, daily 400mg.

6. The concentration of each concentration of light, medium and heavy gravity concentration, can be used for spinal anesthesia, the amount does not exceed 15mg.
 

.

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.
 

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 




Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.

Please feel free to contact me if you need any further information~






 

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