Cell Rep: Discover a metabolic switch that blocks obesity
Cell Rep: Discover a metabolic switch that blocks obesity
November 07, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; You have tried all the diets. No matter what: You still recover your lost weight again, even if you eat healthy and exercise regularly. This may be due to a specific enzyme in the brain: alpha/beta hydrolase domain-6 (ABHD6). In a new study, researchers from the University of Montreal Hospital Research Center in Canada confirmed that when the enzyme is blocked in certain neurons in the mouse hypothalamus, then these mice are unlikely to lose weight, even if they Follow an ideal weight loss program.
The researchers constructed genetically engineered mice that lack the ABHD6 enzyme in a localized region of the brain, a specific group of hypothalamic neurons. The first author of the paper, Alexandre Fisette, explains, “These mice are exactly the same as normal mice under normal accommodation and food conditions. However, when challenged, they are unable to adapt. After fasting, they are not Reconsuming food; they are unable to maintain their body temperature when exposed to the cold; they are more likely to become obese when fed a high-fat diet. More importantly, once they become obese, we try to feed them. A normal diet to make them lose weight, they won't lose weight."
The researchers found that the enzyme acts as a switch in the body's adaptation to extreme conditions. Dr. Thierry Alquier, a co-author of the paper and a professor at the University of Montreal Hospital Research Center, commented, “It is a mechanism we have never suspected. Significantly, the lack of a single enzyme in a precise region of the brain completely destroys normal Metabolism, which prevents these mice from losing weight."
Does the same process happen in the human body? Alquier believes that clinical research is needed to discover this. However, according to Alquier, "ABHD6 plays a key role in the rebound effects often observed after a diet. People who experience difficulty with weight loss may lack this enzyme."
Stephanie Fulton, a co-author of the paper and a researcher at the University of Montreal Hospital Research Center, stressed, "We now know that ABHD6 plays a completely different role in certain neurons in the hypothalamus. Blocking this enzyme at this position promotes obesity. Blocking it elsewhere in the body can have beneficial effects."
A variety of signaling and neural networks are involved in regulating energy balance and maintaining a stable body weight. "We have shown that the ABHD6 enzyme plays a key role in maintaining homeostasis in specific neurons in the hypothalamus," the researchers explained. "But we don't know what happens when we block this enzyme throughout the brain." This is what we are currently working on in an ongoing study."
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