Pharmaceutical Raw Material Metformin HCl / Hydrochloride CAS 1115-70-4
Name:Metformin hydrochloride
CAS:1115-70-4
Formula:C4H12ClN5
Molecular Weight:165.62
Synonyms:Diaformin;Dialon;Diformin;Diformin Retard;Dimefor;Fornidd;Geamet;Glucomin;Glucomine;Gluconil;Glucophage;Glucophage 850;Glumetza;Glumin;Glupermin;Glyceriphage;Glyciphage;Glycon;Metomin;Miformin;N,N-Dimethylbiguanide hydrochloride;N,N-Dimethylbiguanidinium chloride;N1
EINECS:214-230-6
Melting Point:223-226 °C(lit.)
Boiling Point:224.1 °C at 760 mmHg
Flash Point:89.3 °C
Appearance:crystalline solid
Assay: 99%
Storage: The shade seal preservation
Description:
Metformin, marketed under the tradename Glucophage among Others, is the first-line medication for the treatment of type 2 diabetes. This is particularly true in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent thecardiovascular disease and cancer complications of diabetes. It is not associated with weight gain. It is taken by mouth.
Metformin is generally well tolerated. Common side effects include diarrhea, nausea and abdominal pain. It has a low risk of developing low blood sugar. High blood lactic acid level is a concern if the drug is prescribed inappropriately and in overly large doses. It should not be used in those withliver disease or kidney problems. While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes. Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues.
Application:
Metformin hydrochloride is clinically used for the treatment of type diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
Specification:
| Item | Specifications (USP) | Specifications (AJI) |
| Description | White crystals or crystalline powder | White crystals or crystalline powder |
| Identification | Infrared absorption spectrum | Infrared absorption spectrum |
| Specific rotation [a]D20° |
+26.3 °- +27.7° | +26.9 °- +27.9° |
| State of solution /Transmittance |
--- | ≥ 98.0% |
| Chloride (Cl) | ≤ 0.05% | ≤ 0.020% |
| Ammonium (NH4) | --- | ≤ 0.02% |
| Sulfate (SO4) | ≤ 0.03% | ≤ 0.020% |
| Iron (Fe) | ≤ 0.003% | ≤ 10PPm |
| Heavy metals (Pb) | ≤ 0.0015% | ≤ 10PPm |
| Arsenic (As2O3) | --- | ≤ 1PPm |
| Other amino acids | --- | Chromatographically not detectable |
| Loss on drying | ≤ 0.5% | ≤ 0.5% |
| Residue on ignition (sulfated) |
≤ 0.3% | ≤ 0.10% |
| Assay | 98.5-101.5% | 99.0 - 101.0% |
| PH | --- | 10.5-12.0 |
| Organic volatile impurities | Meets the requirements | --- |
Our adwantage:
1, High quality with competitive price:
  1) Standard: Enterprise Standard
  2) All Purity≥98%
  3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
  1) Parcel can be sent out within 24 hours after payment. Tracking number available
  2) Secure and discreet shipment. Various transportation methods for your choice.
  3) Customs pass rate ≥99%
  4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
  1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
  2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
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Quick Detail:Name:Metformin hydrochloride
CAS:1115-70-4
Formula:C4H12ClN5
Molecular Weight:165.62
Synonyms:Diaformin;Dialon;Diformin;Diformin Retard;Dimefor;Fornidd;Geamet;Glucomin;Glucomine;Gluconil;Glucophage;Glucophage 850;Glumetza;Glumin;Glupermin;Glyceriphage;Glyciphage;Glycon;Metomin;Miformin;N,N-Dimethylbiguanide hydrochloride;N,N-Dimethylbiguanidinium chloride;N1
EINECS:214-230-6
Melting Point:223-226 °C(lit.)
Boiling Point:224.1 °C at 760 mmHg
Flash Point:89.3 °C
Appearance:crystalline solid
Assay: 99%
Storage: The shade seal preservation
Description:
Metformin, marketed under the tradename Glucophage among others, is the first-line medication for the treatment of type 2 diabetes. This is particularly true in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent thecardiovascular disease and cancer complications of diabetes. It is not associated with weight gain. It is taken by mouth.
Metformin is generally well tolerated. Common side effects include diarrhea, nausea and abdominal pain. It has a low risk of developing low blood sugar. High blood lactic acid level is a concern if the drug is prescribed inappropriately and in overly large doses. It should not be used in those withliver disease or kidney problems. While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes. Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues.
Application:
Metformin hydrochloride is clinically used for the treatment of type diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
Specification:
| Item | Specifications (USP) | Specifications (AJI) |
| Description | White crystals or crystalline powder | White crystals or crystalline powder |
| Identification | Infrared absorption spectrum | Infrared absorption spectrum |
| Specific rotation [a]D20° |
+26.3 °- +27.7° | +26.9 °- +27.9° |
| State of solution /Transmittance |
--- | ≥ 98.0% |
| Chloride (Cl) | ≤ 0.05% | ≤ 0.020% |
| Ammonium (NH4) | --- | ≤ 0.02% |
| Sulfate (SO4) | ≤ 0.03% | ≤ 0.020% |
| Iron (Fe) | ≤ 0.003% | ≤ 10PPm |
| Heavy metals (Pb) | ≤ 0.0015% | ≤ 10PPm |
| Arsenic (As2O3) | --- | ≤ 1PPm |
| Other amino acids | --- | Chromatographically not detectable |
| Loss on drying | ≤ 0.5% | ≤ 0.5% |
| Residue on ignition (sulfated) |
≤ 0.3% | ≤ 0.10% |
| Assay | 98.5-101.5% | 99.0 - 101.0% |
| PH | --- | 10.5-12.0 |
| Organic volatile impurities | Meets the requirements | --- |
Our adwantage:
1, High quality with competitive price:
  1) Standard: Enterprise Standard
  2) All Purity≥98%
  3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
  1) Parcel can be sent out within 24 hours after payment. Tracking number available
  2) Secure and discreet shipment. Various transportation methods for your choice.
  3) Customs pass rate ≥99%
  4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
  1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
  2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Â
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