Release date: 2017-12-04
Type 2 diabetes affects the health of more than 500 million people worldwide. The cause of the disease is that the beta cells in the islets in the body cannot produce enough insulin to maintain the body's blood sugar levels. Recently, a research report published in the international journal Diabetologia, researchers from institutions such as Dresden University of Technology identified a new class of dysregulated gene clusters in pancreatic islets in patients with type 2 diabetes. The study found or provided new hope for late researchers to develop new therapies for effective treatment of type 2 diabetes.
Researchers hope to find ways to promote the regeneration, maintenance and protection of pancreatic beta cells as a new way to accelerate the development of new therapies and preventive measures for diabetes. First, the researchers wanted to find out the abnormally expressed genes in the β cells of diabetic patients. The changes in the expression of these genes may lead to the lack of β cells in diabetic patients. In this study, researchers based on comparative genomic expression methods for the first time. Islet tissue was collected from an organism of non-diabetic and diabetic organ donors and patients undergoing pancreatic surgery and was analyzed in depth.
The researchers used a new method to group islet tissue from non-diabetic and diabetic patients into a larger collection of studies, and also obtained islet tissue from the body of pre-diabetic patients, who subsequently identified 19 in these islet tissues. Changes in the expression of genes, it is worth noting that for the expression changes of 9 genes, the researchers did not find abnormalities in the islets of diabetic patients. On the other hand, this study did not find any genes in the precursor. Abnormal expression occurs in the islets of the body of diabetic patients, so this suggests that changes in the expression of these genes are a result, rather than the cause of loss of beta cell function in diabetic patients.
In later studies, researchers will look for genes that are abnormally expressed before beta cell disintegration. For this purpose, researchers also need to collect large amounts of islet tissue for accurate analysis. Researcher Professor Michele Solimena pointed out that we believe that the data in this study may provide us with a new molecular field of view to clarify the errors in the body's beta cells, and to open up new research related to type 2 diabetes. Researchers believe that this new method may help to clarify the functional effects of beta cells when overnutrition, so the ability to damage them can meet the body's excess insulin requirements to maintain the body's metabolic homeostasis.
Original source::
Michele Solimena, Anke M. Schulte, Lorella Marselli, et al. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia (2017). DOI: 10.1007/s00125 -017-4500-3
Source: Bio Valley
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