Israel's development of the nano version of "good fast": gently spray a wound to get
Kicking the ball and breaking your leg? Going to the outing to accidentally scratch the skin? If you are naughty when you were young, you may have used the "good fast" this medicine as I did.
I don't know what you think - since I understand how fast I work, I always think that this is an over-packaged, inconsistent, and in some sense the healing effect is exaggerated.
The scientific name is lidocaine chlorhexidine aerosol, which is often used for cuts, abrasions, soft tissue contusions, etc. However, it is actually a purely local anesthetic. The main effect is pain relief with a slight hemostatic effect, and the recovery effect on the actual wound is extremely limited.
Just this year, an Israeli medical technology company invented a new handheld wound treatment machine. It is used in the same way as it is, and it is sprayed on the wound.
However, its greatness lies in the non-contact use, which can immediately produce a uniform coverage of the wound and avoid possible secondary infection during wound treatment.
Although the propellant itself is a liquid, this machine is capable of pumping it into extremely fine nanofilaments that are very strong and retain the anesthesia/hemostatic/therapeutic effect of the propellant itself.
On the wound, the nanofilament becomes the "second skin" of the patient, which protects the whole process of wound healing and even eliminates the need for dressing change . After the wound has healed, this layer of nano material will naturally fall off.
Such a machine contracts the entire task of protecting from wound sterilization and dressing to healing. Its existence eliminates the need for gauze and bandages, greatly reducing the pain of the patient's recovery process.
It's also very simple to use: aim at the wound, buckle the trigger, evenly cover the entire wound, and you're done! Anyone can operate this machine as long as they are trained enough.
How is such a powerful technology realized?
This machine is called SpinCare. The spin in the name comes from a technology that has been around for a long time: electrospinning, or electrospinning.
In simple terms, electrospinning works by applying a sufficiently high voltage to the liquid to form static electricity. The repulsive force of the charge counteracts the surface tension of the liquid, causing the liquid to be disassembled into small droplets, ejected from a point; in the air In the middle, the liquid evaporates and further fibrillates into macromolecular fibers of nanometer order diameter. Electrospinning is often used to produce textiles and polymer materials.
In essence, SpinCare is such a hand-held electro-spinning machine that uses the electrospinning principle to eject the built-in medical fluid fibrillation and attach it to the wound to form a layer of “artificial skinâ€.
Because of tissue exposure, wounds tend to be a breakthrough in bacterial infections. The nano-scale diameter fibers produced by electrospinning make the "artificial skin" slim but strong enough. Because the pore size is too small, the structure is similar to human skin and other tissues, bacteria can hardly pass through this layer of nano skin, natural anti-infective ability, and the protective effect on fragile wounds is much stronger than gauze and bandage.
According to the information provided by Nanomedic, “artificial skin†can always protect the wound once it is attached to the surface of the wound. It does not need to be replaced/replenished and sprayed until it is healed, which eliminates the pain of dressing change. This layer of "artificial skin" is transparent, making it easy for doctors and nurses to check the healing progress of the wound.
And because the electrospinning principle requires the liquid to be "snashed" in the air, the use of SpinCare itself is non-contact, further avoiding infection. As for the nozzle of this machine, it is one-time, and it will be thrown after use. The laser from the machine can assist in aiming.
The company has conducted clinical trials in more than 120 subjects of different genders, ages, and medical history.
Subject 1, male 58 years old, underwent skin graft surgery for the treatment of squamous cell carcinoma. To be on the safe side, the researchers used SpinCare to perform a two-layer overlay on the rectangular skin donor area (170 cm2) and keep it until the donor area heals and creates new skin, which then falls off.
The researchers found that the first layer of nano-skin covered initially achieved good coverage during recovery.
Subject 2, male 18 years old, with no history of disease, with a large area of ​​2 degrees from the neck, left shoulder and upper body to superficial to moderate burns. After basic cleaning with saline, the researchers used SpinCare to cover the burned skin. In order to protect the wound from unnecessary physical shock, the gauze was covered for the first two days and then removed and not used.
The patient reported wound pain at the time of admission (VAS Visual Analog Scale Level 3) and no longer felt pain after covering the nano skin (VAS level 0). The patient was discharged after the third day of injury and was allowed to take a bath. On the seventh day, the injured area was almost completely cured. Compared with the same burn, the nano skin began to fall off.
In the above clinical trials, all 120 subjects did not experience secondary infection. Nanomedic uses its specially made polymer formulation, which does not contain any medically effective ingredients.
Both of the previous cases are extreme, because skin grafting (burns usually rely on skin grafting) can cause severe burns in the donor area, causing huge secondary damage to the patient. SpinCare disinfects, protects, and accelerates wound healing. And have an objective effect on the pain relief for patients .
Due to the applicability of electrospinning, Nanomedic claims SpinCare can be used with a wide range of sprays including, but not limited to, antibacterials and antibiotics (disinfection), collagen and silicone gel (wound repair), and anesthesia pain medications. .
Previously, the FDA passed the certification of another jet-type burn treatment product, ReCell, in September 2018. The product relies on the chemistry of the spray to promote self-regeneration of the wound skin without the use of electrospinning technology.
To be clear, SpinCare has not been certified by the Food and Drug Administration (FDA) in the United States. Considering that electrospinning is not technically complicated, it takes more time to pass the certification.
SpinCare will be a great help in dealing with wounds in emergency rooms, ambulances and military personnel. At the same time, due to its simplicity of use, anyone can use the machine after a few minutes of training, and Nanomedic also plans to enter the home medical machinery market.
The company expects to start mass production after the FDA certification is passed. By then, the cost of electrospun wound treatment will be significantly lower than the frequent, conventional wound treatments that rely on medical professionals.
Source: Creations WeChat public number
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