Under natural conditions, persimmons are refrigerated in the northern regions of China, and the persimmons harvested are placed in a cool place. Let it freeze, and after freezing, move it to the fruit rack at the shade, and keep the persimmon fruit frozen until it is sold in the spring season. The method of refrigerating is to dig four channels with a width of 33 cm and a width of 4 cm on the ground with a width of 4 m and an appropriate degree of gradation, and lay a 7 to 10 cm thick layer of stalks of straw on the bottom surface of the channel. After the frost is frozen, the persimmon is placed thereon. 5 ~6 layers, let it freeze naturally in the open air, then add a 30-60 cm thick covering on top of the persimmon fruit to maintain a stable low temperature. The following year the temperature turns warmer. Then use the earth to plug the channel to prevent the thawing of persimmon fruit to extend the storage period. The refrigerated persimmon fruit can complete the ripening and astringent action of the persimmon with the extension of the storage period. Frozen persimmons are enhanced due to lack of oxygen and respiration. The accumulation of acetone acetaldehyde in fruits and tannins form insoluble tannins, which makes the astringent taste of persimmons disappear, and polysaccharides are hydrolyzed into monosaccharides and become sweet.
Key Intermediates
Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.

for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
Our company specializes in providing key intermediates for various APIs

Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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