Biomedical Technology has raised a maximum of $225 million this year: developing induced pluripotent stem cell therapies
On December 12th, BlueRock Therapeutics, which is dedicated to the development of induced pluripotent stem cells (iPSCs), has invested 225 million US dollars. This kind of financing is rare! This round of financing was jointly funded by Bayer and Versant Ventures, and they have great confidence in the potential of this stem cell technology to cure the disease. Currently, the main goal of BlueRock is to treat patients with myocardial infarction or chronic heart failure and help them regenerate cardiomyocytes. $225 million investment, enough for BlueRock's R&D funding within four years. Versant Ventures revealed that BlueRock's clinical trials will begin in 2018.
Technology: Next Generation Regenerative Medicine Company
BlueRock Therapeutics is known as the “Next Generation Regenerative Medicine Companyâ€, which is distinguished by the patented “Inductive Pluripotent Stem Cells (iPSCs)â€. It was originally obtained by Japanese scientist Shinya Yamanaka in 2006 using viral vectors to transfer four transcription factors (Oct4, Sox2, Klf4 and c-Myc) into differentiated somatic cells and reprogram them. A cell type similar to embryonic stem cells and embryonic APSC pluripotent cells. Professor Yamamoto won the Nobel Prize in Physiology and Medicine in 2012.
Subsequently, different scientists around the world have discovered that other methods can also make such cells. On March 10, 2016, a research team consisting of Professor Ogata Yuki, professor of ophthalmology at Osaka University in Japan, successfully used artificially induced pluripotent stem cells (iPS cells) to develop some corneas, crystals, and retinas. The cells of the site. The results were published in the electronic version of the British science journal Nature on the 9th of this month. This year, the world's top journals "Nature" and "Cell" also wrote an essay to commemorate the first decade of iPSCs technology invention.
Unlike techniques such as oogonium stem cells, this great technology that changes the world is directly recoded with a human skin cell, blood cell or other cell, converted into iPSCs, and then differentiated into stem cells, nerve cells or anything else that needs to be regenerated. Cell. Not only can it avoid the risk of immune rejection, but it can also avoid ethical controversy.
Clinical: Helping patients with maculopathy to see the light again
What is the potential of iPSCs technology for disease treatment? In 2008, Harvard University's George Daley Lab used induced cell reprogramming technology to transform skin cells from patients with 10 different genetic diseases into iPS, which will play an important role in building disease models and drug screening.
In 2009, Chinese scientists used iPS stem cells to develop mice in November 2008. The work done by the research team led by researcher Zhou Qi of the Institute of Zoology of the Chinese Academy of Sciences and the researcher led by Dr. Zeng Fanyi of the School of Medicine of Shanghai Jiaotong University showed that the use of iPS stem cells can obtain viable and reproducible mice, thus proving the first time in the world. iPS stem cells have similar pluripotency to embryonic stem cells. Studies have shown that iPS stem cells may be as a potential source of treatment for various diseases as embryonic stem cells.
In clinical trials, iPSCs were only performed in Japan in 2014 for 10 years, and helped patients with macular disease successfully regained their light, but due to two tiny genetic mutations, the experiment was in 2015. The year was still unfortunately called to stop.
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