Chinese scientists discover new pathways for tumor immune escape
January 07, 2019 Source: Ministry of Science and Technology
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];On December 21, 2018, a team of Chinese scientists, Professor Yaping, from the Department of Immunobiology, Yale University, USA, published a study entitled "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3" on the international top magazine Cell. The paper, the study found a new pathway for tumor immune escape: the LAG-3-FGL1 pathway.
Lymphocyte-activation gene 3 (LAG-3), as an immunological checkpoint receptor that transmits an inhibitory signal, plays an important role in tumor immune escape; however, it plays an immunosuppressive function. The ligand remains unclear. The team screened the binding protein of LAG-3 by Genome-scale receptor array (GSRA) technology and finally found that Fibrinogen-like protein 1 (FGL1) is a major component of LAG-3. Binding protein. By blocking the LAG-3-FGL1 pathway, the body's immunity and clearance of tumors can be improved, and synergistic with anti-PD-1 treatment.
This achievement will help open a new era of tumor immunotherapy as a new potential therapeutic target, providing a new opportunity for tumor immunotherapy.
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