Tumor diagnosis is expected to be completed by "photographing"
August 20, 2018 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];After years of research, the team of Professor Zhang Fan from the Department of Chemistry of Fudan University has made important progress in the field of near-infrared fluorescence lifetime imaging. Their research indicates that tumor disease is expected to be diagnosed by non-invasive near-infrared fluorescence lifetime imaging technology, and no longer need to be diagnosed by surgical sectioning. Related papers were recently published in Nature·Nanotechnology.
Fluorescence is a common luminescence phenomenon in nature. Fluorescent probe media has long been used for imaging detection of living tissues. However, in the past, researchers focused on fluorescence imaging in the visible region and the near-infrared first window, just like in Taking pictures with the camera at night is not only difficult to capture distant objects, but the noise in the imaging is also very clear. Later, the scientists found that in the second window of the near-infrared, the "breakage rate" of light in the penetration of biological tissues such as skin and fat is small, and the deep tissue imaging of the organism can be better realized. However, further research has found that the imaging technique is often unsatisfactory in practical multi-image imaging applications.
After hard work, Zhang Fan team proposed a "multiple imaging method based on time dimension", which uses the rare earth nanoprobe fluorescence lifetime signal with fluorescence emission in the second window region of near infrared to achieve multiple imaging of living body. When the fluorescent probe is excited by a near-infrared laser, the absorbed energy of the probe will jump from the ground state to the excited state. When the excitation light is removed, the fluorescence intensity of the probe is reduced to the maximum fluorescence intensity at the time of excitation (1/e). The time required is the fluorescence lifetime.
The team found in the experiment that the fluorescence lifetime is relatively stable and will not change as the depth of the biological tissue changes. According to the quantitative fluorescence lifetime, Zhang Fan team selected rare earth nanoparticles with lower toxicity and stronger bleaching ability for experiments. After a long period of research and precise regulation, this new imaging technology was successfully applied to the accurate diagnosis of breast cancer tumors, and satisfactory results were obtained. Subsequently, multiple tumor markers were quantitatively detected, and the results showed that it was clinically traditional. The results obtained by the detection technology are highly consistent.
The “Time Dimensional Multiple Imaging Method†replaces the original biopsy procedure with “photographingâ€, which not only directly avoids the risk of tumor cell metastasis, but also reduces the human error that may be caused by traditional methods in tissue sectioning, processing and scoring. Judging risk, it is expected to become a new type of non-invasive tumor diagnosis method.
Zhang Fan said that the research is still in the laboratory stage, and further research is needed. (Reporter Sun Guogen correspondent Han Yunru)
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