On the 6th, from the Yunnan Agricultural University, the research team of the school recently found the main components of tea polyphenols to inhibit the wounds of diabetic wounds and promote the healing and healing of skin wounds in diabetic mice. Journal of the American Society for Experimental Biology "This result was published online. It is reported that it is also the first natural monomer active ingredient found in the world to promote the healing of diabetic wounds.
EGCG is epigallocatechin gallate, which is the main component of tea polyphenols. It is a catechin monomer isolated from tea, which has antibacterial, antiviral, antioxidative, antithrombotic, anti-inflammatory and Anti-tumor and other effects.
Professor Sheng Jun's team used biomolecular interaction technology, cell model and animal model to systematically study the molecular mechanism of EGCG in tea to promote skin wound healing in diabetic mice by targeting membrane receptors. The results showed that it can significantly inhibit the inflammatory target signal pathway, macrophage accumulation and inflammatory response in wound skin of diabetic mice, and it is proved that it directly acts by binding to the target membrane receptor.
The team evaluated the effects of EGCG on diabetic wound healing. On the wound model of diabetic mice, the wounds of diabetic mice were observed to heal significantly during the proliferative phase by continuous application. The healing rate of the mice in the EGCG-treated group was increased by about 18% compared with the model group, which was close to the normal group. Further studies confirmed that EGCG binds to inflammatory targets, attenuates the inflammatory response and inflammatory factor levels of macrophages in skin wound tissues of diabetic mice, and reducing inflammation is the main mechanism for promoting skin wound healing in proliferating diabetic mice.
Previously, the research team was the first in the world in May 2017 to prove that the anti-inflammatory target receptor of EGCG is Notch. The anti-inflammatory effect of EGCG works by inhibiting the target, and the diabetic wound is difficult to heal because of the high expression of the target. And the result of long-term inflammation. The research provides a scientific basis for the development of natural medicines that promote the healing of diabetic wounds, and the research team is accelerating the development of related drugs. (Reporter Zhao Hanbin)
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