effect
(1) Anti-aging effects Many scholars believe that a large number of lipid peroxidation products accumulate in aging animals, accompanied by a decrease in the activity of superoxide dismutase. The experimental results showed that Polygonum multiflorum can significantly reduce the content of malondialdehyde in the brain and liver tissue of aged mice, increase the content of monoamine neurotransmitters in the brain, enhance the activity of SOD, and significantly inhibit monoamine oxidase-B in brain and liver tissues of aged mice. Activity, thus eliminating the damage of free radicals on the body, delaying the occurrence of aging and disease. Free radical theory believes that the formation and deposition of lipid peroxides can cause a series of symptoms of aging. Therefore, the content of lipid peroxides is one of the main indicators for evaluating aging, and the extract of Polygonum multiflorum on lipid peroxidation of mouse skin. The production of the substance has a very obvious inhibitory effect, indicating that the Polygonum multiflorum has the effect of delaying skin aging and can be used as a good skin anti-aging cosmetic additive. In addition, Polygonum multiflorum can significantly increase the ability of repairing DNA damage in peripheral lymphocytes of aged rats. By inhibiting the activity of monoamine oxidase-B in the brain, it affects the content of central neurotransmitters in organisms, thereby regulating central nervous activity and delaying brain aging.
(2) Effects on the immune system Polygonum multiflorum can antagonize the atrophy and degeneration of mouse thymus caused by the immunosuppressant hydrocortisone or prednisolone, increase the weight of thymus, adrenal glands, spleen and celiac lymph nodes, increase the total number of white blood cells, and promote The phagocytic function of peritoneal macrophages reduces the content of circulating immune complexes in mice. According to immunology, the decline of immune function is closely related to the aging of the body. The thymus is the central organ of the immune system and can effectively maintain the body's immune function. Polygonum multiflorum can delay the degeneration of thymus with aging, which may be an important mechanism for delaying aging and improving immunity. In addition, Heshenwu can also increase the content of thymus nucleic acid and protein, delay the aging of thymus in aged rats, and can promote the reversal of changes in the ultrastructure of thymus in old mice, and increase the phagocytic index of mouse peritoneal macrophages. The body's non-specific immune function.
(3) Experimental study on the hypolipidemic and anti-atherosclerotic effects showed that the preparation of Polygonum multiflorum extract 0.84-8.4 g/kg·d was intragastrically administered, and plasma triglyceride and free cholesterol levels were significantly reduced within 6 weeks. Inhibits the increase of plasma total cholesterol and cholesterol esters. The aqueous extract of Radix Polygoni multiflori can significantly increase serum HDL-C levels, reduce TC levels, and significantly increase the ratio of HDL-C/TC, suggesting that Polygonum multiflorum can improve the body's ability to function and remove cholesterol, and lower blood lipid levels. Delays the development of atherosclerosis. The mechanism of lipid-lowering effect of Polygonum multiflorum has not yet been clarified, and may be accomplished by one of the following approaches or collaboratively:
1 The diarrhea effect of steroids accelerates the metabolism of toxic substances in the body and restores the fat metabolism pathway in the liver.
2 It effectively affects liver 3-hydroxy-3-methylglutaryl coenzyme A reductase and Ta-hydroxylase activity, inhibits endogenous cholesterol synthesis, promotes the conversion of cholesterol to bile acids, and inhibits bile acid reabsorption from the intestine Enhance the excretion of bile acids from the intestinal tract;
3 Induces liver microsomal carboxylesterase, promotes the hydrolysis process in the body, and accelerates the excretion of toxic substances in the body.
There are many links in atherosclerotic lesions, and proliferation of smooth muscle cells is an important part of this process. Experiments show that the compound Chinese medicine containing Radix Polygoni multiflori can obviously inhibit the proliferation of bovine aortic smooth muscle, and the effect of the single herb is not as effective as the prescription. Chen Wansheng et al. found that a new tetrahydroxystilbene glycoside in Shouwuwu can inhibit the platelet-derived growth factor-induced proliferation of calf vascular smooth muscle cells, and the inhibitory rate can reach 50.6% at 10 -4 mol/L. This is why the anti-atherosclerosis effect of Shouwu provides experimental basis.
(4) Myocardial protection Dai Youping found that the extract of Polygonum multiflorum had a preventive effect on myocardial ischemia-reperfusion injury in dogs. Its role in the link may be Polygonum multiflorum stilbene glycosides, resveratrol glycosides increase the function of superoxide dismutase (SOD) and catalase. In addition, some components of Polygonum multiflorum, such as terpenoids and phospholipids, have a direct antioxidant effect, reducing oxygen free radicals in the body.
(5) Hepatoprotective effect of stilbene glycoside contained in Polygonum multiflorum on fatty liver and liver function damage in rats caused by peroxide corn oil, elevated lipid peroxide content in liver, elevated serum alanine aminotransferase and aspartate aminotransferase, etc. The antagonistic effect can also significantly reduce serum free fatty acids and hepatic lipid peroxides. In vitro, it can also inhibit the lipid peroxidation of rat liver microsomes induced by adenosine diphosphate and reduced coenzyme, reduce liver cell damage and have a good liver protection. In addition, Polygonum multiflorum is rich in lecithin, which makes it possible to supplement or promote synthesis of a variety of lecithin-reduced liver diseases and prevent fatty liver and cholesterol deposition. However, the effect of Hedyamony on increasing hepatic glycogen is also beneficial to the protection of the liver.
(6) Neuroprotective effect, the main active ingredient in Polygonum multiflorum Thunb.: Stilbene glucoside has a significant antagonistic effect on the survival rate of nerve cells induced by β-amyloid protein and hydrogen peroxide and increase of lactate dehydrogenase leakage. As the dose increases, its neuroprotective effect increases. It is suggested that stilbene glucoside has certain effects on prevention and treatment of degenerative diseases of the nervous system such as Alzheimer's disease. The extract of Radix Polygoni multiflori can inhibit the production of interleukin and nitric oxide in a concentration-dependent manner, thereby exerting neuroprotective effects.
(7) Antimicrobial effect of Polygonum multiflorum decoction of different processed products against Staphylococcus aureus, Staphylococcus aureus, Shigella flexneri, Shigella sonnei, Salmonella typhimurium 901. Salmonella typhimurium B, diphtheria bacillus, Streptococcus henryi, Chennai The cardinomycetes have different degrees of inhibition, in which the decoction of raw Shouwu is more resistant to Staphylococcus aureus than other processed products, while the decoction of the first Shouwu is decoction against white staphylococci and the liquor is decocted with Shouwu decoction. The decoction of Dioscorea chinensis and Dioscorea chinensis was better than that of crude drugs and other processed products.
(8) Other effects Polygonum multiflorum has an adrenocortical hormone-like effect. Shouwu can significantly increase hepatic glycogen content in adrenal dearthed mice, and can significantly increase the weight of adrenal glands in mice and prevent the occurrence of Chaihu and hydrocortisone. Thymus and adrenal glands shrink. In addition, the anthraquinone derivatives contained in the root of Polygonum multiflorum can promote bowel movements and have a slight diarrhea effect.
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