"Cell": MIT finds the key genetics of leukemia
On February 2, 2017, "Cell" magazine published David M. of the Massachusetts Institute of Technology online. Sabatini Fellow and Eric S. A research paper by Lander Researcher reports a set of key genes in 14 human acute myeloid leukemia (AML) cell lines that are required for cell proliferation and survival. Combining this "gene necessity map" with existing genomic information will help in the development of new therapies.
In this study, the researchers focused on the genes and protein pathways associated with the Ras oncogene. The Ras gene is an oncogene that is frequently mutated in human cancer and plays an important role in acute myeloid leukemia and other cancers.
Tim Wang, the first author of the paper, said: " In most cases, mutants of the Ras protein are considered to be ' undruggable '. However, the alternative is to find other genes that the Ras mutant depends on, I hope that one of them will become a drug target. Unfortunately, this ' Ras synthesis lethal ' gene is still difficult to determine. "
Using CRISPR-based genetic screening technology, the researchers used a comprehensive assessment of the impact of 18,000 protein-coding genes on the human genome. Analysis of these data and subsequent work revealed the molecular function of previously unrecognized genes and identified lethal interactions with Ras mutants. David Sabatini, senior author of the paper and MIT, said: " This process allows us to identify the list of genes necessary for Ras mutant cells. "
Surgical Tape,Adhesive Flexible Tape,Waterproof Surgical Tape,Breathable Surgicaltape
Zhende Medical Co.,Ltd , https://www.zhendemedicals.com