Cell "glue" is expected to develop new biomaterials
Release date: 2014-09-03
Recently, a research report published in the international magazine Sci. Technol. Adv. Mater , researchers from the University of Milan revealed through research that a synthetic protein called AGMA1 may promote brain cells under laboratory conditions. The ability to adhere, which is a new way of thinking and direction for the effective improvement of cell-to-cell adhesion.
For a long time, the neural cells in the original organisms have been isolated and cultured in the laboratory to study the metabolic process of the brain. However, the brain cell culture fluid with increased adhesion promoter may promote the adsorption and diffusion between cells. , growth and morphological development. Improving cell-cell adsorption for biomaterials is a major challenge in neural tissue engineering, and it is also critical for the development of tissues implanted by neurosurgery, such as cochlear implants, biosensors (such as biosensors). Wait).
The positively charged synthetic protein covering the negatively charged cell membrane may promote the adsorption and elongation of nerves. However, most synthetic proteins are toxic to living cells, which need to be removed from the toxic effect in the cell suspension; In the nervous system, extracellular matrices such as collagen and laminin promote the regeneration, differentiation, adsorption and migration of nerve fibers. The protein sequences found in collagen and laminin may serve as the smallest sequence to mediate the adhesion of many cells, such as nerve cells.
The researchers say that AGMA1 is a basic synthetic protein that is biocompatible, water-soluble, carries a positive charge, and has a protein sequence similar to that in collagen and laminin, compared to conventional synthesis. In terms of sex proteins, AGMA1 is less toxic and can be easily used in inexpensive biological materials. The researchers examined the potential of AGMA1 and found that it promotes the adhesion, proliferation and differentiation of primary brain cells in the laboratory under laboratory conditions.
In the end, the researchers said that AGMA1 has considerable advantages over conventional synthetic proteins, so it is the best candidate protein for adherent cells to promote cell proliferation and differentiation, and it is also a very important way to develop new biomaterials. Good "raw material".
Source: Bio Valley
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