Dalian University of Technology develops an organ-like microfluidic chip with simulated physiological functions
Before the market, the new drugs need to carry out a large number of preclinical drug screening processes such as pharmacokinetics, toxicity and activity evaluation. The traditional methods are mainly animal tests. The animal test cycle is very long, costly, and there are ethical disputes. In particular, the metabolic systems of animals and humans are very different, and there is a great risk in directly applying the results obtained by animals to the human body. The various drawbacks of the animal testing process have become the main bottleneck affecting drug research and development on a global scale.
After a number of years of painstaking research, the research team led by Prof. Lin Bingcheng from Dalian University of Technology, Dalian Institute of Chemical Technology and Dalian Institute of Chemical Technology, has developed a multi-functional micro-flow of organ-like organs that allows multiple cells and tissues to coexist in vitro. Control chip, the chip can simultaneously measure the absorption, distribution, metabolism, elimination and other pharmacokinetic parameters of the drug, conduct anti-tumor and hepatotoxicity evaluation of the drug, and initially possess the function of the test animal, the chip consists of several basic modules It is composed of top-down connections in turn, which can be flexibly combined, scale-integrated, and the cell and tissue types and stacking order of modules can be arbitrarily changed according to actual needs, and pharmacological and pharmacological studies are carried out for microfluidic tissue-organ chips. The final step in replacing preclinical animal testing is an important step.
The results of "A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process" were published in Nature. The magazine's sub-collection "Scientific Reports" was funded by the Ministry of Science and Technology's major new drug creation project (2013ZX09507005001).
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