Pharmacological effects
1. Effect on the cardiovascular system 1.1 The effect on the isolated cardiac heart According to the Yagi isolated heart apparatus,
20 ml of Renshi liquid perfusion, 0.1 g hematopora chinensis was added to the perfusate (0.5%). Mild inhibition was observed on the isolated heart, and the systolic force was decreased, the heart rate was decreased (P<0.05), and the cardiac output was decreased. Decrease (P<0.01).
1.2 Effect on isolated aortic strips in rabbits Aortic strips of isolated rabbits were placed in an external device sink (37 ± 0.5 degrees) for 1 hour, and 0.2 ml of the extract (1 g crude drug/ml) was added to 20 ml of Kirschner. In the fluid (1%), the blood vessel began to show marked contraction, which was blocked by phentolamine, suggesting that the contraction may be related to a-receptor. Subsequently, a lasting relaxation effect gradually emerged.
1.3 The effect on isolated porcine coronary artery The experimental method is the same as above. 0.2ml extract was added to 20ml of Kirschner's solution. Norepinephrine and potassium chloride were used for positive and negative reaction control. The hourly effect was associated with rabbit aortic strips. similar. However, in the contraction state caused by potassium chloride, adding drugs, the contraction no longer occurs, and immediately relax the blood vessels, suggesting that the treatment of coronary artery spasm is beneficial.
1.4 Effects on Experimental Myocardial Infarction in Animals 1.4.1 Effect of Scorpin Water-Soluble Extracts on Experimental Myocardial Infarction in Rabbits Blood-soluble extracts of Hedysarum sinensis (Chinese herbal medicine was cold leached with 95% ethanol, concentrated under reduced pressure, and extracted with ether. Ether-soluble substance, syrup-like precipitate Add water to the precipitation no longer occur, filter the precipitate, add gelatin solution to the precipitate no longer produce, the aqueous solution is concentrated under reduced pressure to a syrup, methanol extraction, methanol insoluble matter, made of water solvent, containing sugar Classes and Apes). Twenty-four healthy rabbits were randomly divided into three groups, the control group (equal physiological saline), the water extract of Scutellariae group (100 mg/kg; equivalent to 100 g of the original drug), and propranolol group (0.05 mg/kg). Anesthesia was performed with sodium pentobarbital (300 mg/kg) and chest multi-lead electrocardiogram was performed. Open the chest and use a No. 4 silk thread at the root of the left anterior descending branch. Closing the chest, tracing the electrocardiogram immediately after the iv drug, and then inject every 6 hours, a total of 4 times. Electrocardiogram tests were performed 4 hours and 24 hours after ligation. After 24 hours, the heart was removed and the percentage of myocardial infarction range was calculated. The total number of millivolts of ST-segment elevation in the ECG of the Daxueteng and propranolol groups was 4 hours after ligation of the left anterior descending artery in each group of rabbits. ST) similar, the two groups were significantly lower than the control group (P <0.05. The difference was more significant at 24 hours after ligation (P <0.01). At 24 hours after ligation, the myocardial infarction range of the Daxueteng group was reduced to 19.17% In comparison with the control group, 19.88% of the patients in the concomitant Dean group were significantly different from the control group (Pkg saline, Dagtaileng group ivl00mg/kg body weight, and propranolol group iv propranolol 0.05mg/kg body weight). Lactic acid content in myocardium of rabbits in the group.Results Before administration, there was no significant difference in mean ∑ΔST between myocardial infarction control group, Daxueteng group and propranolol group (P>0.05), which was caused by ligation of the left anterior descending branch. Myocardial ischemia may be similar between the 3 groups: myocardial infarction animals 1 hour after administration of saline or drugs, myocardial infarction group 1 hour after myocardial infarction, myocardial tissue lactic acid content was significantly increased, while the Sedum group and experience No increase in the safety group (relative to the normal myocardium lactic acid content ), Extremely significant difference (P <0.001), thus indicating cuneata water soluble extract can improve myocardial lactate metabolism disorders.
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