Release date: 2017-11-29
It was learned from Nantong University that Associate Professor Chen Jinling and the University of Texas Medical Department jointly published a research report in the Cell Report, revealing the ability of type I interferon IFN-λ to resist Zika virus infection. The card virus provides a theoretical basis for the diagnosis and treatment of pregnant women with adverse pregnancy.
Adults infected with Zika virus mostly have no obvious symptoms or mild symptoms. But children born to mothers with Zika virus during pregnancy are not so lucky. Zika virus is currently the only arbovirus that can pass through (or) infect the placenta and cause abnormal fetal development. Pregnant women infected with Zika virus can cause abnormal fetal development, including spontaneous abortion, intrauterine growth retardation and microcephaly.
Chen Jinling found in the study that fetal rat type 1 interferon (IFN-I) has an antiviral effect. She mated wild-type female rats with IFNAR-/- male mice to construct a pregnant mouse model. After the pregnant mice were infected with Zika virus in the second trimester, no stillbirth was observed, and the virus level in the mother was significantly decreased. In this model, pregnant mice lack a type 1 interferon signal, but the fetal mouse has a relatively intact IFN-I signal. This indicates that the fetal mouse IFN-I signal not only confers the ability of the fetus to resist Zika virus, but also provides feedback to assist the mother against Zika virus. While IFN-λ has both the dual characteristics of type I interferon and interleukin-10 family, in vitro culture, it was found that IFN-λ can significantly inhibit Zika virus replication.
This study clarified the correlation between the adverse pregnancy outcomes caused by Zika virus and the time of infection, revealing the ability of IFN-λ to resist Zika virus infection, not only theoretically deepening the understanding of the Zika virus-induced adverse pregnancy mechanism, but also In practice, the protective effect of IFN-λ on the maternal-fetal interface was confirmed, which provided a theoretical basis for the further application of IFN-λ in the treatment of Zika virus patients, especially pregnant women infected with Zika virus.
Source: Technology Daily
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