Hey, you don't know: these companies have invested heavily in "Second Genomics"

Previously, "Microbiology Industry Report (Part 1)" briefly described the technological development of microbiology, and there were questions from entrepreneurs, investment institutions, and industry researchers, and the microbial genome as the "second genomics" of the human body. Will it have the same application model as human genomics? Can the application of microbiology be able to replicate the application of genomics? Are the opportunities and challenges of microbiology and genomics similar?

Microbiology has similar upstream and midstream, but has not exactly the same downstream

From a technical point of view, microbiology and genomics are based on gene sequencing . At present, the instruments and consumables for gene sequencing are mainly monopolized by several major instrument manufacturers in the United States; the middle reaches are sequencing services and build corresponding databases, but The downstream is not exactly the same.

In the steady state of the human body, microbiome and human genomics are not two independent individuals. Through the study of two omics, the mystery of the interaction between a large number of microorganisms and the host is further explored. Microbial and human genomics complement each other, and the combination of the two can achieve the effect of "1+1>2", bringing additional increments. The combination and use of human microbiology and human genomics in research and application is the true research and application of "human genomics".

At present, human genomics is mainly used in the field of clinical medicine, and the main target for the C-end mass users is non-invasive prenatal examination (NIPT). Gene genetic data is formed by genetic testing, and data information is provided for the development of gene therapy through analysis of a large number of samples.

In contrast, microbial genomics is not limited to the application of clinical medicine, but also in the field of nutrition and health:

Genetic diagnosis: The diagnosis of the human genome is mainly applied to diseases caused by genetic mutations, the most common being tumors, which can be used to predict metabolic diseases and cardiovascular diseases, but the prediction accuracy cannot reach 100%. Microbial genomics mainly through the sequencing of the genome of the flora, through the analysis of the composition of the flora, the most common is the disease caused by the imbalance of intestinal flora; a large number of studies have shown that many metabolic diseases and flora imbalance have a certain Correlation. Because the changes in the flora are dynamic, they affect the prediction of some diseases.

Nutritional health: The human genome seems to be useless, and the microbial genome can be used. As early as in the 19th century in Europe, many scientists are studying the application of microbes in the field of nutrition and health, including the current food giant Nestlé. Henry Nestlé studied milk powder for infant nutrition and intestinal microbes, and the products transformed through these studies have made such a trillion-level company. With the development of microbial genomics, more microbes are associated with nutritional health care.

Human microbiology

It can be seen that the application of human microbial genomics in the downstream is very extensive.

Here, the shell detector selects three applications of microbial detection, microecological drugs and fecal bacteria transplantation for simple analysis.

The fastest microbial genomics application in the country - microbial detection

Microbial detection is the fastest growing in the microbial genome industry model, and it is also the first technology transfer in China. Nowadays, the most common microbial detection in China is based on the sequencing of 16S rRNA genes by second-generation sequencing. The composition of microbial organisms is analyzed, which is mainly used for the detection of intestinal flora.

At present, the number of companies focusing on microbial gene testing in China is much lower than that of human genetic testing. Except for the top domestic gene sequencing technology companies such as Huada Gene, most companies that focus on microbial gene testing are generally established in 2014. Later, it is interesting to note that the founding teams of such companies are more or less from the BGI gene.

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