A new tool to guide tumor resection: nano fluorescence sensor
Release date: 2016-12-26
According to a new study, a novel nano-fluorescence sensor can specifically “turn on†and fluoresce in tumor tissue, helping doctors to accurately remove tumor tissue and retain normal tissue to the greatest extent. The study was published in Nature. - Biomedical Engineering magazine.
According to researchers, this breakthrough technology is applicable to any type of tumor, and they will conduct human clinical trials next year.
According to reports, the researchers injected the nanoprobe into the tumor tissue of mice, and once exposed to the tumor cells, the probe will open and illuminate the tumor tissue.
"This suggests that human tumor tissue is more acidic than normal tissue, and we are taking advantage of this feature of tumor tissue," said co-author Baran Sumer, a surgeon at the University of Texas Southwestern Medical Center. .
Surgery is the treatment of choice for many tumors. However, it is still a huge challenge to completely remove tumor tissue and retain normal tissue as much as possible, because current imaging techniques are not sensitive enough to accurately distinguish between tumor tissue and non-tumor tissue.
The new technology uses clinically approved fluorescent dyes that can be imaged by standard cameras being used in hospitals around the world. This nanoprobe acts like a sensor, and it only turns on and fluoresces when the pH of the environment is below the threshold.
The researchers conducted experiments in a mouse head and neck cancer model. They found that the probe used in surgery has great specificity and sensitivity, and it can even illuminate tumor nodules less than 1 mm in diameter.
“This probe can accurately map the tumor to the surgeon when performing an operation,†says Sumer.
This is a nanoscale switching technology, and no technology has so far been so accurate.
“Preparing such probes is relatively simple and therefore not costly,†explains Sumer. “I firmly believe that this technology can be used to detect tumor boundaries in humans.â€
Source: Bio Valley
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