American medical school uses 3D to print functional capillaries
It is reported that bioengineers and scientists at Rice University and Baylor College of Medicine in the United States have begun to combine human endothelial cells and mesenchymal stem cells to 3D print functional capillaries. These capillaries can transport blood in a system that greatly facilitates the manufacture of vascularized tissue. This research has been published in BioMaterials Science.
The study deserves attention because the research team has been able to make capillaries from cells collected from any patient. Not only that, but with such specific cells, the researchers believe that it is possible to create tissues and replacement organs that are easily accepted by the patient's body, eliminating the risk of graft rejection.
"Our research has important therapeutic implications because it demonstrates that we can use human cells and monitor their tubule formation potential in real time as they form the original vascular network," the researchers said. "We have confirmed that these cells have the ability to form The capillary structure, whether it is made of natural material fiber protein or semi-synthetic material gelatin gelatin (GelMA). GelMA is an interesting material that can be printed in 3D at any time and can be used in future tissue engineering applications."
“Ultimately, we want to use live cells to 3D bioprints of fully vascularized tissue for treatment. To achieve this, we need to better understand the mechanical and physiological aspects of neovascularization and the impact of bioprinting on these processes. We are using 3D bioprinting to create tissue with large blood vessels that can be connected to the vascular pump, and use this technology to help us form the smallest capillaries to better nourish new tissue," the researchers said.
This research puts humans a step closer to 3D printing organs. In addition, the study may also facilitate immediate research such as drug testing.
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