"Genetic scissors" can prevent retinopathy
July 26, 2017 Source: Xinhua News Agency
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The gene editing technology commonly known as "gene scissors" shows the potential of medical applications. American researchers used "genetic scissors" in animal experiments to successfully prevent retinal angiogenesis and achieve the purpose of preventing retinopathy.
Retinal angiogenesis refers to the growth of new, abnormal blood vessels on the surface of the retina. As the disease progresses, these new blood vessels leak, rupture and even cause the retina to fall off, causing visual impairment or even blindness. Proliferative diabetic retinopathy, wet age-related macular degeneration, retinopathy of prematurity, etc., may cause retinal angiogenesis.
At present, vascular endothelial growth factor inhibitors are mainly used to inhibit the growth of new blood vessels and reduce vascular leakage. However, such treatments require continued use, and a significant number of patients do not respond to vascular endothelial growth factor inhibitors.
Researchers at the Massachusetts Eye and Ear Hospital in the United States reported in a new online edition of the British journal Nature Communications that previous studies have shown that vascular endothelial growth factor receptor-2 plays an important role in angiogenesis, so they In this attempt, the gene encoding this receptor was edited with an adeno-associated virus as a vector to block pathological angiogenesis in the eye.
The results showed that in the experimental mice, only one injection of adeno-associated virus could complete the gene editing and block the retinal angiogenesis.
Gene editing technology can modify the DNA strand coding as people edit text. This experiment uses the most popular CRISPR-Cas9 technology in the world. The research team said that the next step is to use this gene editing technology to develop new therapies, clinical treatment of eye diseases characterized by pathological intraocular angiogenesis.
They will next focus on the safety and efficacy of this therapy. "Our current animal experiments show that CRISPR-Cas9 technology is a precise and effective tool with the potential to treat angiogenesis-related eye diseases."
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