British researchers use in vitro cells to develop a complete thymus
Release date: 2014-08-29
The University of Edinburgh recently published a press release stating that the school's researchers succeeded in using cell-recombinant technology to produce fully functional thymus using laboratory-cultured cells. This is the first time scientists have used in vitro cells to produce a complete living organ, which is of great significance for the development of new therapies for diseases such as low immune function.
In the study, the researchers first extracted fibroblasts from mouse embryos and transformed them into a completely different type of cell using cell recombination techniques. The recombinant cells are not only identical in appearance to thymocytes, but also have the ability to support T cell development. Subsequently, the researchers mixed the recombinant cells with other thymocytes and transplanted them into mice. These cells eventually developed into living organs with the same structure and function as the mature thymus.
According to the press release, this is the first time that scientists have used cell recombination technology to develop intact living organs using cells in vitro.
"Our research has taken a critical step in nurturing the goal of clinically used artificial thymus," said Professor Claire Blackburn of the MRC Center for Regenerative Medicine at the University of Edinburgh.
The thymus is an important lymphoid organ of the body, located near the heart, and is vital to the immune system because it produces T cells that fight infection. For the treatment of thymic diseases, injection of immune cells into the body or thymography after birth is the main treatment, but these treatments are not universal due to donor scarcity and matching problems. This new research at the University of Edinburgh is expected to change this dilemma.
Although the researchers said that more research is needed to safely and controllably apply this research to the clinic, whether it is genetically affected and thymic dysplasia, or older adults with severe thymus shrinkage due to age. And will benefit from it in the future. In addition, patients with bone marrow transplants can also benefit, as new therapies may help them quickly rebuild the immune system after bone marrow transplantation.
Source: Technology Daily
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