Japanese scientists find compounds that inhibit cancer cell metastasis
The research team at Kyushu University in Japan discovered a protein that plays an important role in cancer cell survival and metastasis, and found compounds that prevent it from continuing to function.
It has been previously known that the proliferation and metastasis of cancer cells with variant genes is due to the activation of "RAC" molecules leading to changes in cell morphology, and it is difficult to develop drugs that can directly control RAC, so the researchers turned their attention to RAC activation. On the molecule.
The Japanese team found a protein called "DOCK1" among many RAC-related molecules. After genetic manipulation, the DOCK1 protein could not be expressed, and it was found that the infiltration of cancer cells into surrounding tissues and the absorption of nutrients from outside the cells slowed down, and the viability of cancer cells decreased. The research team judged that DOCK1 plays a key role in the activation of RAC molecules. In order to inhibit the activation of RAC, they screened "TBOPP" compounds that block DOCK1 activity from about 200,000 compounds, which were used to transplant cancer cells and found that cancer cells metastasized and tumors increased. It was suppressed and no obvious side effects were found.
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