Korean scientists have found that adding a small molecule to the drinking water of Alzheimer's disease mice can reduce amyloid plaques in the brain of mice and improve learning and memory in mice. This new chemical molecule is called EPPS and is short for 4-hydroxyethylpiperazinepropanesulfonic acid. This EPPS molecule did not adversely affect the health of mice even at high doses. Scientists hope to conduct further research to determine whether EPPS is safe and effective for humans and Alzheimer's disease. Related research was published in Nature Communications.
Alzheimer's disease is the most common form of Alzheimer's disease. According to the US Centers for Disease Control and Prevention, the disease affects more than five million Americans and will grow to 14 million by 2050. The sixth most common cause of death in Alzheimer's disease in the United States. In a small number of cases, especially early-onset Alzheimer's, it seems to be hereditary, but the mechanism behind this is not clear. An early sign of Alzheimer's disease is called amyloid beta, which forms a granular plaque deposit in the brain. Current Alzheimer's drugs attempt to prevent the formation of these plaques, which may slow the progression of symptoms. However, it is not easy to remove these amyloid precipitates.
The research team led by YoungSoo Kim of the Institute of Brain Science, Korea University of Science and Technology in Seoul, commissioned the study of the adsorption of EPPS molecules on the precipitation of these amyloid particles and the ability of this molecule to convert precipitated plaques into simple molecules. Through a series of experiments, they found that EPPS can reduce amyloid deposits in the brain in living mice. They also found that the molecule can be added to drinking water and persist in the blood and across the blood-brain barrier. YoungSoo Kim believes that EPPS can penetrate the barrier because it is a relatively small molecule. Taking EPPS up to 2000 mg/kg body weight per day did not appear to have significant toxic effects on mice. Although this may seem like a safe chemical molecule, YoungSoo Kim believes that more tests are needed to determine the exact toxic side effects and how to apply it to human clinical trials.
Scientists have discussed whether beta-amyloid accumulation is the cause of Alzheimer's disease or the result of the disease. YoungSoo Kim believes that because of his team's research, the removal of learning and memory in mice after removal of amyloid plaques in the brain, the study of supported β-amyloid deposits is Alzheimer's disease. One of the incentives. The research team will also work to continue research on the safety of EPPS, which, if used in human clinical trials, will be important for the ageing social health cause.
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