Cancer is one of the world's leading causes of death. Its main feature is the uncontrolled growth of tumor cells in an uncontrolled manner. Its rapid growth requires a lot of energy. Scientists are considering "starving" tumor cells by blocking the nutrition and energy supply chains of tumor cells. In the "Natural-Cell Death and Disease" published in June, an article by Chinese scientists was published, pointing out that the use of certain components of Tibetan Ganoderma lucidum can significantly inhibit the proliferation activity of liver cancer cells. In layman's terms, it is "starved to death". cancer cell.
British scientists have discovered that a protein called NF-kappa-B plays an important role in the process of acquiring energy from tumor cells. If it inhibits the function of this protein, it will increase the possibility of starving cancer cells.
Later, German scientists discovered that by adjusting the diet, glucose intake can be reduced. Cancer cells that rely on sugar for a long time will die quickly under a continuous low-sugar diet.
However, things are not so simple.
In the first case, the NF-kappa-B protein is inhibited by drugs, blocking the pathway of energy conversion, and it is possible to starve some cancer cells. However, because the human body structure is very complicated, if the application is not accurate, not only some cancer cells will be "starved to death", some healthy cells will be "starved to death", and the spread of cancer cells is even more difficult to search. The injured one thousand lost to eight hundred, which is not worth the candle.
In the second case, many cancer patients have low immunity, especially in the process of chemotherapy, which may result in low appetite. Nutrition can't keep up. If you don't eat well, sugar and starch are not enough. The result may be that cancer cells are not "starved" and people are starved to death.
So, is there any new way to go in the research direction of "starving" tumor cells?
Through the continuous screening, scientists from the Institute of Microbiology of the Chinese Academy of Sciences and other research institutions have obtained anti-tumor new drug lead molecules that can specifically block the energy supply of tumor cells.
The growth of tumor cells requires a lot of energy, and they also require the participation of nucleic acids, fatty acids and amino acids. Tumor cells meet the needs of bioenergy and biosynthesis by modulating the metabolism of these important components.
In lipid metabolism and related metabolism, there is a protein called fatty acid binding protein. This protein plays a major role in the metabolic pathway and is an important target for the development of anticancer drugs. That is to say, anticancer drugs can treat diseases of the human body by acting on this protein.
Chinese scientists use Ganoderma lucidum to achieve "starved" tumor cells.
Ganoderma Lucidum is a rare and rare Chinese medicine that has always played the role of immortality in China and is widely used as a functional food and traditional medicine in Asian countries. Tibetan Ganoderma Lucidum is a rare Ganoderma lucidum variety that grows only in the high and cold regions of Tibet. Its pharmacological composition is very rich. Ganoderma lucidum, a natural organism, exerts its anti-tumor effect by affecting lipid-related metabolic pathways.
How does Ganoderma lucidum work?
In the inner membrane of mitochondria in animal cells, there is a substance called "cardiolipin", and 15% of cardiolipin is present in the myocardium. Scientists have found that changes in cardiolipin can cause changes in cell mitochondria. Cardiolipin is closely related to normal cell mitochondria and closely related to cancer cell mitochondria. Because cancer cells are also cells, cardiolipin can cause changes in cells, which in turn can lead to changes in cancer cells.
In 2014, Xiong Weiping, a researcher at the Vegetable Institute of the Tibet Academy of Agriculture and Animal Husbandry, first realized the artificial cultivation of Tibet's rare medicinal fungus, white meat, and carried out research on active ingredients in cooperation with the Chinese Academy of Sciences. Not long ago, researcher Liu Hongwei of the Institute of Microbiology of the Chinese Academy of Sciences and researcher Sun Chaoyu of the Qingdao Institute of Oceanography of the Chinese Academy of Sciences used Tibetan Ganoderma lucidum as a research material to separate and extract a novel triterpenoid compound, GL22, from Ganoderma lucidum. GL22 is a wonderful compound that inhibits a protein, causing a decrease in the steady-state level of cardiolipin, leading to abnormalities in the mitochondria of cells closely related to cardiolipin, which ultimately leads to cancer cell death.
In summary, the wonderful compounds in Ganoderma lucidum "starved" cancer cells by lowering the level of cardiolipin that cancer cells depend on.
In addition, the researchers have a better finding: in the experiment, the wonderful compound of GL22 in Ganoderma lucidum can not only effectively inhibit the growth of liver cancer cells, but also has no obvious toxic and side effects on the body, effectively reducing the normality. The effects of cells. This feature has shown excellent application prospects in the field of anti-liver cancer drug research and development.
The research of Chinese scientists has further confirmed the medicinal and economic value of the large fungus of Ganoderma lucidum.
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