The human plasma proteome genetic map is open to help identify new therapeutic targets for "new use of old drugs"
June 07, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];British "Nature" magazine published a new genetics on the 6th: Cambridge University research team quantified more than 3,000 proteins in human plasma, successfully mapped the human plasma proteome genetic map, 89% of which were previously unknown. The association between genetic variation and individual protein levels found in this study may mean that new therapeutic targets can be identified by this and existing drugs can be used to treat new diseases.
Plasma protein refers to the protein portion of plasma. There are hundreds of known plasma proteins in recent years, but the function of some proteins has not yet been elucidated. Plasma proteins are essential for a variety of biological processes, including growth, repair, signaling, transportation, and resistance to infection. They are important drug targets and are often subject to differential regulation during disease progression. However, due to the limited scope of research in the past, little is known about the genetic factors that determine individual plasma protein levels.
This time, researchers at the University of Cambridge, Benjamin Sun, Adam Butterworth, and colleagues studied DNA short-strands that bind to specific molecular targets (aptamers/aptamers) to quantify the plasma of 3301 healthy individuals. 3622 proteins in the middle. The samples in their study were taken from a research project called “INTERVALâ€, a study of nearly 50,000 British blood donors aimed at improving the UK's national health care system by determining the optimal blood donation interval ( NHS) blood supply.
The team identified 1927 associations between the genomic region and 1478 proteins—89% of which were previously unknown. The researchers found that there is considerable overlap between these positions and regions that regulate gene expression, suggesting that protein levels are usually, but not always, determined by gene expression levels.
In addition, the research team identified the specific genetic variants they studied in association with previously identified areas associated with common diseases. Understanding the relationship between disease, genetic variation, and specific protein levels will have great hopes to pave the way for the identification of new therapeutic target proteins and "new use of old drugs," while also helping to identify currently developing drugs. potential risks. (Reporter Zhang Mengran)
Editor-in-chief
Scientific progress is constantly exploring the isolation phenomenon, summarizing and inducing the law, and then returning to the exploration of guiding the case. Blood is the basic system on which humans depend for life. It is found that blood components, blood typing, and blood index range... Our now-experienced vital signs are derived from the statistics and analysis of large amounts of data, and plasma proteins are no exception. In the future, on our blood donation certificate, we will mark out what kind of special protein we have donated.
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