Progress in the production of anticancer drug raw materials with bacteria
June 08, 2017 Source: Xinhua News Agency
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Danish researchers have reported that they have successfully used E. coli to produce an important class of bioactive substances, cytochrome P450, which is expected to be used in the mass production of anticancer drugs such as paclitaxel. The results were completed in collaboration with researchers from the Biosafety Center of the Novo Nordisk Foundation in Denmark and the University of Copenhagen. The papers were published in the new issue of the journal Biotechnology and Bioengineering.
Cytochrome P450 is a class of enzymes that play an important role in the process of biological metabolism. Previous studies have shown that some of these members can be used to synthesize anticancer drug active ingredients such as paclitaxel.
Some plants can use cytochrome P450 to synthesize a variety of "chemical weapons" to protect against pests and diseases and harsh environments. However, plants can only produce trace amounts of cytochrome P450, and the extraction process is complicated and easily contaminated. In addition, some related plants are endangered and cannot be used in industrial production.
Danish researchers have developed a genetic tool that successfully produces about 50 cytochrome P450 enzymes from different strains of E. coli, including varieties that can be used to synthesize the anticancer drugs paclitaxel and macrosterols.
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