Wearable devices are expected to subvert Parkinson's disease

Release date: 2015-05-19

As a Chinese, you probably won't know a set of data: there are currently about 5 million Parkinson's patients worldwide, and the Chinese account for 47%. As China's aging problem continues to increase, it is expected that by 2030, the number of patients with Parkinson's disease in China will account for 57% of the world. Among them, about 65% of Parkinson's patients in Chinese cities are misdiagnosed and missed, and the undiagnosed rate of this disease in rural areas is as high as 90%. The latest epidemiological survey shows that the prevalence of Parkinson's disease in urban population over 65 years old is close to 2%.

This group of seemingly shocking numbers is also the driving force for scientists to pursue. Recently, Wang Shouyan, a researcher at the Medical Technology Research Laboratory of the Suzhou Medical Institute of the Chinese Academy of Sciences, and Liu Chunfeng, the deputy dean of the Second Affiliated Hospital of Suzhou University, have developed a set of co-constructed Suzhou Key Laboratory of Neuroengineering Technology. Wearable Parkinson's disease quantitative assessment device.

Diagnosis: prototype comes out

At first glance, this device looks like a watch: a stylish black strap and a white dial. It can be worn on the wrist and ankle of patients with Parkinson's disease when using it.

Don't look at its appearance, it uses a nine-axis motion sensor, including a three-axis accelerometer, a three-axis gyroscope and a three-axis magnetometer to accurately sense the movement of the patient's hands and feet, and upload the test data via Bluetooth 4.0. To smart terminals (smartphones or tablets), a specially developed quantitative evaluation algorithm analyzes the severity of symptoms such as tremor and bradykines in real time.

Researchers told reporters that the biggest feature of Parkinson's disease is that there will be gait and movement disorders. People will experience dizziness, inability to walk normally, and changes in speech sounds, and these characterizations can be received by sensors. Ideal for testing with wearable devices.

"Because the jitter is intermittent, nervousness and strange environment will affect the patient's symptoms. I often hear the clinician report that the patient is in normal condition when he is visiting the doctor. The doctor knows that the home is shaking very hard." Wang Shouyan said.

With it, doctors can break the limits of time and space and monitor patients in real time. In the past, the patients seen by the doctors were in the hospital. They saw individual patients, and they were all in a specific place, and could not monitor the whole condition of the patients. Patients with Parkinson's disease may be shaking every day, and may not shake intermittently. The doctor's most expectation is to use a terminal to break the time and space constraints and monitor the patient's exercise data in real time.

"Further, although Parkinson's disease is not high enough, it is enough to make patients' lives full of pain. The dependence of this disease requires strong participation of doctors." Wang Shouyan told reporters. Parkinson's patients wear this "watch" for a long time in their daily lives, dynamically monitoring the development of the disease, and monitoring data can provide an important therapeutic reference for neurologists. This "watch" can not only solve the problem that the doctor can not continuously monitor the patient's condition for a long time and the current limitation of the severity of Parkinson's disease by using the scale method, but also avoid the subjective feeling of the patient and the examiner. influences. Therefore, the needs of both doctors and patients are very strong.

The reporter learned that at present, this equipment has completed the first version of the prototype, applied for 4 national patents, and has carried out clinical tests in several top three hospitals to collect patient data. At the same time, researchers are working on a second version of prototype improvements and supporting industrial design work.

Treatment: Twilight has been

Currently, drug treatment is the most common method for Parkinson's disease. However, long-term use of drugs can have serious side effects, that is, the "switching effect" in medicine: when taking drugs, the patient moves freely and is in an "on" state; once the drug is effective, the patient's activity becomes Difficulties, that is, entering the "off" state, this switch fluctuations continue to develop in a vicious cycle until the end of the patient's life.

"The results of chemical interventions in drug therapy are not always satisfactory, some patients have no effect and the side effects after long-term treatment are also worrying." Wang Shouyan said, "At the same time, there are more than 200,000 patients in the country who are going to have surgery, Parkinson's, high. The cost of surgery and rehabilitation also puts the patient's family overwhelmed."

The team of Wang Shouyan and the University of Oxford are working on the development of medical research instruments that are intelligent deep brain stimulation techniques to alleviate the symptoms of Parkinson's disease.

"The physical intervention of deep brain stimulation is long-term treatment through minimally invasive surgery, with few side effects and reversible control." Wang Shouyan expressed optimism about the application prospects of this project.

He showed the reporter a video that a woman with Parkinson's disease could not stand up before treatment and could stand on the stool and walk slowly after treatment. She used the smart deep brain stimulator device they developed. This set consists of 8-channel neural signal recording, real-time signal processing, and 4-channel arbitrary waveform electrical stimulator. "It will further improve the current therapeutic effect of deep brain stimulation."

In addition, they are developing an intelligent light stimulator with amazing performance. The reporter saw that a light-sensitive protein transgenic mouse wearing a smart light stimulator can remotely control the stimulator by wireless, and it can rhythmically crawl as long as it is stimulated.

"If this technology can be realized in the clinic as soon as possible, for patients with Parkinson's disease, the future will be resumed in a free life." Wang Shouyan said.

Wang Shouyan wears a prototype

Source: Chinese Journal of Science

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