Zhang Feng discovers the new function of "Magic Scissor" CRISPR: it can be used for nucleic acid detection
On April 13th, Science magazine published an important research progress entitled "Nucleic acid detection with CRISPR-Cas13a/C2c2". A team of scientists from institutions such as the Broad Institute and the McGovern Institute has transformed the CRISPR-targeted CRISPR system, making it a fast, inexpensive and highly sensitive diagnostic tool. This discovery is expected to have a transformative impact on scientific research and global public health. Cisco pioneer Zhang Feng and James J. of the Broad Institute. Collins is the co-author of the study.
Specifically, this paper describes how the RNA-targeted CRISPR enzyme (Cas13a/C2c2) “transforms†a highly sensitive “detectorâ€: the presence of a single molecule in a target RNA or DNA molecule (the presence of As little as a single molecule of a target RNA or DNA molecule). This new tool was awarded the title of SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) by the researchers. They believe that one day, this technology may be used to deal with viral and bacterial outbreaks, to monitor antibiotic resistance and to detect cancer.
SHERLOCK combines CRISPR-Cas13a withisothermal RNA amplification to detect RNA and DNA with single-basespecificity.
Six applications
Scientists have demonstrated the versatility of the SHERLOCK technology in a number of different applications: 1) detecting the presence of Zika virus in a patient's blood or urine sample within a few hours; 2) distinguishing the genetic sequences of the Zika strains in Africa and the United States; 3) Identify specific bacterial types, such as E. coli; 4) Detect antibiotic resistance genes; 5) Identify cancer mutations in simulated free DNA; 6) Quickly read human genetic information.
Zhang Feng said: "The Cas13a enzyme can produce such extraordinary sensitivity. This is very exciting."
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