People often say that taking medicine and taking medicine is actually the same as eating medicine and eating. The enema in traditional Chinese medicine indicates that the absorption of Chinese medicine into the human body is the key. How to improve the efficacy of traditional Chinese medicine is actually how to improve the absorption rate of the human body. Fineness is a very critical factor. The Chinese medicine pulverizer mainly uses mechanical force (also by other methods) to split the bulk solid material into an appropriate size operation process. The purpose of the pulverization is to increase the surface area of ​​the drug, promote the dissolution and absorption of the drug, and improve the biological activity of the drug. The degree of utilization adjusts the fluidity of the drug powder. It improves the uniformity of different powder mixtures to facilitate the preparation of various dosage forms. The ultrafine pulverization technology is a rapidly developed internationally in the past 20 years for cell-level pulverization. The new technology has been widely used in deep processing of traditional Chinese medicine due to its simple operation. The process of solid drug pulverization is called the degree of comminution. It is usually expressed as the ratio (n) of the average diameter (d) of the material before pulverization to the average diameter (d1) of the pulverized material, that is, n=d/d1.
The pulverizing process of traditional Chinese medicines is formed into a certain shape by the cohesive force between the molecules. The pulverization process of solid drugs generally uses external mechanical force to partially destroy the cohesive force between the molecules of the materials, so that the block of the drug is reduced and the surface area is increased. Large, that is, the process of converting mechanical energy into surface energy. The amount of external force used should be determined by the hardness and performance of the drug.
The external forces during the pulverization process include: impact force, compression force, shear force, bending force, grinding force, etc. Impact, crushing and grinding are effective for brittle substances, and shearing is more effective for fibrous materials. The force and the compressive force are the main ones, and the shearing force and the grinding force are the main components. In fact, the pulverizing process is the result of the combined action of the above several forces. The dissolution of the active ingredients in the Chinese medicinal materials is achieved by the concentration gradient. In the coarse powder of the medicinal material, each coarse particle is composed of several intact cells, and the medicinal components in the outer layer of cells are outwardly concentrated according to the concentration gradient, and need to pass through the cell wall of the body to be dissolved into the human digestive juice. Then, the medicinal ingredients in the cells and in the cells are not outward in the same way, and need to pass through several layers of cell walls. If the active ingredient in the drug is vegetable water; the dissolution of the active ingredients mainly depends on the surface activity in the human digestive juice. The agent component penetrates into the cell structure and combines with the drug component to form a hydrophilic structure, and then goes outward according to the concentration ladder, and the speed is very slow. Because the substance stays in the human body for a limited time, the absorption utilization is not high. The cell structure is the main factor affecting the dissolution of the drug; if the cell structure is broken, the active ingredient can be directly dissolved and the speed is greatly accelerated. This is what we call the ultra-fine crushing of Chinese medicine, and Shijiazhuang Benchen's heavy-pressure grinding type ultra-fine grinding machine is such a machine that is very suitable for the ultra-fine grinding of traditional Chinese medicine.
According to the results of the experiment conducted by Shijiazhuang Benchen Electromechanical Equipment Co., Ltd. in China University of Traditional Chinese Medicine with a heavy-pressure grinding type superfine pulverizer, if the traditional Chinese medicine can reach such a fine level, it is the level of the broken wall that people say long. The absorption rate of the effect is hundreds of times or even higher than that of common medicinal materials. The traditional Chinese medicine pulverized by this machine is especially suitable for the finer and more uniform particle size, the specific surface area is increased, the porosity is increased, the drug can be well dispersed, and dissolved in the gastrointestinal fluid. And the contact area with the gastrointestinal film is increased, and it is more easily absorbed by the gastrointestinal tract. Whether it is a topical patch or an oral capsule, after the ultrafine pulverization, the original dose can be achieved with a small dose, and the pressure is heavy. The grinding type ultrafine pulverizer is specially designed for the ultrafine pulverization of traditional Chinese medicine, especially for the pulverization effect of fibrous materials. Smashing Chinese herbal medicine can generally reach 300-5000 mesh. The ultrafine pulverization treatment of traditional Chinese medicine can greatly improve the efficacy of the drug, and many domestic and foreign scientific research institutions have reported. The bioavailability of saponins of American ginseng is only 2% after oral administration. It can be contained after ultrafine pulverization and directly absorbed through the oral mucosa. Qian Zifen of Peking Union Medical College Hospital reported that the intestine effect of a powdery cassia seed is equivalent to 4-5 parts of granular cassia. The texture of the medicinal materials with a hard texture and tight organization will increase even more.
Through the above, we can more clearly understand the important position of traditional Chinese medicine fineness in the utilization of traditional Chinese medicine. It is precisely because of this reason that various Chinese medicine manufacturers are constantly proposing new crushing requirements. Chinese medicine crusher manufacturers are constantly introducing models suitable for Chinese medicine crushing. The benign interaction between the two has made the Chinese medicine crusher industry have made great progress in the past ten years. Benchen Electromechanical Co., Ltd., as a local enterprise of Shijiazhuang, which has been engaged in the research and development of traditional Chinese medicine crusher, has long been a product with excellent product quality and individuality. The function has won wide recognition from the users of Shijiazhuang, especially the newly launched Chinese medicine superfine crushing series in recent years. It has been inspired by the ancient medicine roller ancient ship. After modern processing and advanced equipment processing, the machine is currently crushed in traditional Chinese medicine. The industry has achieved great success. We welcome all Chinese medicine crushing manufacturers to visit our company for more product information, or come to our company to visit the experiment. We are dedicated to providing you with * products and services~!
Surgical Packs,Sterile Surgical Packs,Disposable Surgical Packs,Medical Disposable Surgical Packs
Xinxiang Huaxi Sanitary Materials Co., Ltd. , https://www.huaximedical.com